ParkinsonCanadaV1, Main, Exploration, bibRecord, 001219

Hormone-induced 14-3-3γ Adaptor Protein Regulates Steroidogenic Acute Regulatory Protein Activity and Steroid Biosynthesis in MA-10 Leydig Cells*

Identifieur interne : 001219 ( Main/Exploration ); précédent : 001218; suivant : 001220

Hormone-induced 14-3-3γ Adaptor Protein Regulates Steroidogenic Acute Regulatory Protein Activity and Steroid Biosynthesis in MA-10 Leydig Cells*

Auteurs : Yasaman Aghazadeh ; Malena B. Rone ; Josip Blonder ; Xiaoying Ye ; Timothy D. Veenstra ; D. Buck Hales ; Martine Culty ; Vassilios Papadopoulos

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2012.

RBID : PMC:3346089

Abstract

Background: The mechanism mediating hormone-induced steroidogenesis involves multiprotein complexes.

Results: 14-3-3γ is identified as a hormone-induced regulator of STAR function.

Conclusion: 14-3-3γ negatively regulates steroidogenesis by interacting with STAR, acting in a buffer capacity to sustain the STAR-mediated steroid formation for prolonged periods of time.

Significance: Characterizing the mechanisms regulating steroidogenesis contributes to our understanding of how steroids are synthesized.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346089

DOI: 10.1074/jbc.M112.339580
PubMed: 22427666
PubMed Central: 3346089

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 The mechanism mediating hormone-induced steroidogenesis involves multiprotein complexes.</p>
<p><bold>Results:</bold>
 14-3-3γ is identified as a hormone-induced regulator of STAR function.</p>
<p><bold>Conclusion:</bold>
 14-3-3γ negatively regulates steroidogenesis by interacting with STAR, acting in a buffer capacity to sustain the STAR-mediated steroid formation for prolonged periods of time.</p>
<p><bold>Significance:</bold>
 Characterizing the mechanisms regulating steroidogenesis contributes to our understanding of how steroids are synthesized.</p>
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<name sortKey="Hales, D Buck" sort="Hales, D Buck" uniqKey="Hales D" first="D. Buck" last="Hales">D. Buck Hales</name>
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La maladie de Parkinson au Canada (serveur d'exploration)

Hormone-induced 14-3-3γ Adaptor Protein Regulates Steroidogenic Acute Regulatory Protein Activity and Steroid Biosynthesis in MA-10 Leydig Cells*

Hormone-induced 14-3-3γ Adaptor Protein Regulates Steroidogenic Acute Regulatory Protein Activity and Steroid Biosynthesis in MA-10 Leydig Cells*

Source :

Abstract

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